Home All anti-BRCC3 antibodies
Anti-BRCC3 Antibody EPR4366
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Also for BRCC3 (NM_024332)
|A synthetic peptide corresponding to residues in human BRCC36 was used as an immunogen.|
|Human, Mouse, Rat
||FC: 1:100 - 500, IP: 1:10 - 100, WB: 1:10,000-50,000,
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens BRCA1/BRCA2-containing complex, subunit 3 (BRCC3), transcript variant 1|
|BRCC36; C6.1A; CXorf53; RP11-143H17.2|
|BRCC36 is a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. It is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains, and does not have activity toward 'Lys-48'-linked polyubiquitin chains. In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint (1).|
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Western blot analysis on (A) HeLa, (B) MCF-7, (C) SKBR-3, and (D) 293T cell lysates using anti-BRCC36 RabMAb .
Flow cytometric analysis of permeabilized HeLa cells using anti-BRCC36 RabMAb (red) or a rabbit IgG (negative) (green).