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 Home All anti-BRCC3 antibodies

Anti-BRCC3 Antibody EPR4365

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Specifications Related Products Conjugation/Bulk FAQs
SKU Description Amount Price Availability*  
TA307048
  • Rabbit monoclonal antibody against BRCC36(clone EPR4365)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC411291) , 20ug
 100ul $325 3-7 Days
TA802519S
  • Purified GAPDH mouse monoclonal antibody (Loading control), clone 2D9
 30ul
$100
$50*		 In Stock
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* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human BRCC36 was used as an immunogen.
Clone NameEPR4365 IsotypeRabbit IgG
Species ReactivityHuman, Mouse, Rat Concentration
Guaranteed Application *WB Suggested DilutionsICC: 1:50 - 100, IP: 1:10 - 100, WB: 1:1,000 - 10,000,
Buffer50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Reference Data

Target NameHomo sapiens BRCA1/BRCA2-containing complex, subunit 3 (BRCC3), transcript variant 1
Alternative NameBRCC36; C6.1A; CXorf53; RP11-143H17.2
Database LinkNP_077308
FunctionBRCC36 is a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. (1). It is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains, and does not have activity toward 'Lys-48'-linked polyubiquitin chains. In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). BRCC36 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. It is aberrantly expressed in the vast majority of breast tumors (2). This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint (1).
Related Pathway

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WB Image
Western blot analysis on (A) MCF-7, (B) SKBR-3, (C) 293T, (D) fetal kidney, and (E) HeLa cell lysates using anti-BRCC36 RabMAb .

 

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