Home All anti-BRCC3 antibodies
Anti-BRCC3 Antibody EPR4365
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for BRCC3 (NM_024332)
|A synthetic peptide corresponding to residues in human BRCC36 was used as an immunogen.|
|Human, Mouse, Rat
||ICC: 1:50 - 100, IP: 1:10 - 100, WB: 1:1,000 - 10,000,
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens BRCA1/BRCA2-containing complex, subunit 3 (BRCC3), transcript variant 1|
|BRCC36; C6.1A; CXorf53; RP11-143H17.2|
|BRCC36 is a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. (1). It is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains, and does not have activity toward 'Lys-48'-linked polyubiquitin chains. In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). BRCC36 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. It is aberrantly expressed in the vast majority of breast tumors (2). This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint (1).|
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
Western blot analysis on (A) MCF-7, (B) SKBR-3, (C) 293T, (D) fetal kidney, and (E) HeLa cell lysates using anti-BRCC36 RabMAb .