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Home Antibody All anti-BRCA2 antibodies

Anti-BRCA2 Antibody

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SKU Description Amount Price Availability*  
TA323750 Anti-BRCA2 Rabbit Polyclonal Antibody 100ul $325 2-3 Weeks
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OriGene Data

ImmunogenSynthetic peptide corresponding to a region derived from 110-124 amino acids of Human Breast cancer type 2 susceptibility protein
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.3mg/ml
Guaranteed Application * Suggested DilutionsELISA: 1:1000-5000, WB: 1:200-1000
Predicted MW Explanation 384kDa
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens breast cancer 2, early onset (BRCA2)
Alternative NameBRCC2; BROVCA2; FACD; FAD; FAD1; FANCD; FANCD1; GLM3; PNCA2; XRCC11
Database LinkNP_000050
Entrez Gene 675 Human
Entrez Gene 12190 Mouse
Entrez Gene 360254 Rat
FunctionInherited mutations in BRCA1 and this gene; BRCA2; confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability; specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif; and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene; as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
Related PathwayDruggable Genome Homologous recombinationPathways in cancerPancreatic cancer

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* OriGene provides validated application data and protocol, with money back guarantee.

 

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