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Anti-BRCA1 TRUEMAB Antibody Clone OTI6H10

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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SKU Description Amount Price Availability*  
TA802733 BRCA1 mouse monoclonal antibody, clone OTI6H10 (formerly 6H10) 100ul $325 In Stock
CF802733 Carrier-free (BSA/glycerol-free) BRCA1 mouse monoclonal antibody, clone OTI6H10 (formerly 6H10) 100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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WB(2)

OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 1151-1473 of human BRCA1 (NP_009225) produced in E.coli.
Clone NameClone OTI6H10 IsotypeIgG1
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB Suggested Dilutions WB 1:2000,
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens breast cancer 1, early onset (BRCA1), transcript variant 1
Alternative NameBRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Database LinkNP_009225
Entrez Gene 672 Human
FunctionThis gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
Related PathwayTranscription FactorsDruggable Genome Ubiquitin mediated proteolysis

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* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY BRCA1 (RC219679, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-BRCA1.
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Western blot analysis of  HT29 cell lysate (35ug) by using anti-BRCA1 monoclonal antibody. Dilution: 1:500
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