Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF)
Synonyms:
B-RAF1; BRAF1; NS7; RAFB1
Immunogen
A phospho specific peptide corresponding to residues surrounding threonine 401 of human B-Raf was used as an immunogen. This antibody detects B-Raf phosphorylated on threonine 401.
Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
B-Raf, also know as c-Rmil, is a Serine/Threonine protein kinase member of the Raf family which includes Raf-1 and A-Raf. B-Raf is involved in the transduction of mitogenic signals from the cell membrane to the nucleus (1). Composed of three conserved region (CR1, CR2, CR3) B-Raf is expressed primarily in the brain and in the nervous system (2). It has been observed that MAPK is activated by B-Raf in response to nerve growth factor (3). More than 60% of malignant melanomas were found to contain a specific mutation, B-Raf (V599E) the product of which possesses constitutive kinase activity (4). Mutations in B-Raf have also been identified in lung cancer and non-Hodgkin lymphoma.
Related Pathway
Focal Adhesion
MAPK signaling pathway
Senescence and Autophagy
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