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Home Antibody All anti-BNIP3L antibodies

Anti-BNIP3L Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306045
  • Rabbit Polyclonal Bnip3L Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401379) , 20ug
100ug 325 In Stock
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WB(1)
IHC(1)
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Also for BNIP3L (NM_004331)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenBnip3L antibody was raised against a peptide corresponding to amino acids 77 to 92 of human origin, which are identical to those of mouse Bnip3L.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens BCL2/adenovirus E1B 19kDa interacting protein 3-like (BNIP3L)
Alternative NameBNIP3a; NIX
Database LinkNP_004322
FunctionMembers in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bnip3L, Bnip3alpha, and Nix (for Nip3-like protein X) (1-3). Bnip3L/Bnip3alpha/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis (2,3). Bnip3L interacts with and overcomes suppresses by Bcl-2 and Bcl-xL. Bnip3L is localized in mitochondria. The messenger RNA of Bnip3L is ubiquitously expressed in human tissues (1,2). Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic mitochondrial proteins.
Related Pathway
Apoptosis

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WB Image
Western blot analysis of Bnip3L in K562 whole cell lysate in the absence (A), or presence (B) of immunogenic peptide (2289P) with Bnip3L antibody (IN) at 1 ug/ml.
IHC Image
Immunohistochemical staining of human kidney tissue using Bnip3L antibody at 2 ug/ml.

 

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