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Home Antibody All anti-BMPR2 antibodies

Anti-BMPR2 Antibody


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SKU Description Amount Price Availability*  
TA323210 Anti-BMPR2 Rabbit Polyclonal Antibody 100ul 325
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Also for BMPR2 (NM_001204)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenFusion protein corresponding to a region derived from C terminal 250 amino acids of human bone morphogenetic protein receptor, type II (serine/threonine kinase)
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1.1mg/ml
Guaranteed Application *IHC Suggested DilutionsELISA: 1:2000-5000, IHC: 1:25-100
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2)
Alternative NameBMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1; T-ALK
Database LinkNP_001195
Entrez Gene 659 Human
Entrez Gene 12168 Mouse
Entrez Gene 140590 Rat
FunctionThis gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs; which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors; but they require their respective type I receptors for signaling; whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension; both familial and fenfluramine-associated; and with pulmonary venoocclusive disease.
Related PathwayProtein KinaseTransmembraneDruggable Genome Cytokine-cytokine receptor interactionTGF-beta signaling pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

Predicted cell location: Cytoplasm. Positive control: Human esophagus cancer tissue. Recommended dilution: 1/25-100 The image on the left is immunohistochemistry of paraffin-embedded human esophagus cancer tissue using BMPR2 antibody at dilution 1/35, on the right is treated with the fusion protein. (Original magnification:x200)


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