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Home Antibody All anti-BMI1 antibodies

Anti-BMI1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306298
  • Rabbit Polyclonal BMI-1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401584) , 20ug Explanation
100ug 325 In Stock
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WB(1)
IF(1)
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Also for BMI1 (NM_005180)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenBMI-1 antibody was raised against a peptide corresponding to 15 amino acids near the center of human BMI-1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 - 2 ug/ml, ICC: 10 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens BMI1 proto-oncogene, polycomb ring finger (BMI1)
Alternative NameFLVI2/BMI1; PCGF4; RNF51
Database LinkNP_005171
Entrez Gene 648 Human
Entrez Gene 12151 Mouse
Entrez Gene 307151 Rat
FunctionThe transcriptional repressor BMI-1 was first identified as a proto-oncogene frequently activated by Moloney murine leukemia proviral insertions in mice and cooperating with c-myc in the generation of mouse lymphomas . BMI-1 is involved in segment specification, cell growth and maintenance, transcriptional regulation, and chromatin modification. A major target of BMI-1 is the ink4a locus which encodes tumor suppressor proteins p16 and p19Arf, which are important in tumor progression and thought to be critical in cell proliferation and senescence (2). Recent studies have also shown that BMI-1 is required for the maintenance of adult normal and leukemic stem cells (3), suggesting that BMI-1 could an attractive therapeutic target for stem cell proliferation and renewal as well as for anti-cancer strategies.
Related PathwayES Cell Differentiation/IPSTranscription FactorsDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of BMI-1 in K562 cell lysate with BMI-1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.
IF Image
Immunocytochemistry of BMI-1 in K562 cells with BMI-1 antibody at 10 ug/mL.

 

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