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Home Antibody All anti-BMF antibodies

Anti-BMF Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306104
  • Rabbit Polyclonal Bmf Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424040) , 20ug Explanation
100ug 325 In Stock
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WB(1)
IF(1)
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Also for BMF (NM_001003940)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenBMF antibody was raised with a synthetic peptide corresponding to 15 amino acids near the amino terminus of human BMF.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 2 ug/ml, ICC: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens Bcl2 modifying factor (BMF), transcript variant 1
Alternative NameFLJ00065
Database LinkNP_001003940
Entrez Gene 90427 Human
Entrez Gene 171543 Mouse
FunctionApoptosis is related to many diseases and development. Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3-only proteins, including Bad, Bid, Bik, Hrk, Bim, Noxa, and PUMA, form a growing subclass of the Bcl-2 family. A novel BH3-only protein was recently identified in human and mouse and designated Bmf (for Bcl-2-modifing factor) (1). The BH3 domain in Bmf is required both for binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell's actin cytoskeleton. Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiating the downstream apoptotic program (1,2). Bmf is constitutively expressed in many tissues (1,2).
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Bmf expression in human HepG2 (lane 1) and 293 (lane 2) cell lysates with Bmf antibody at 2 ug /ml.
IF Image
Immunocytochemistry of Bmf in HeLa cells with Bmf antibody at 10 ug/mL.

 

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