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Home Antibody All anti-BLNK antibodies

Anti-BLNK Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308826
  • Rabbit polyclonal antibody to B-cell linker protein (B-cell linker)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC426448) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IF(1)
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Also for BLNK (NM_001114094)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenSynthetic peptide corresponding to a region within amino acids 394 and 456 of BLNK (Uniprot ID#Q8WV28)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Mouse, Rat, Bovine) Concentration1mg/ml
Guaranteed Application *WB, IF Suggested DilutionsICC/IF:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 50kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Mouse (100%), Rat (100%), Bovine (100%)

Reference Data

Target NameHomo sapiens B-cell linker (BLNK), transcript variant 2
Alternative NameAGM4; BASH; bca; BLNK-S; LY57; SLP-65; SLP65
Database LinkNP_001107566
Entrez Gene 29760 Human
Entrez Gene 17060 Mouse
Entrez Gene 499356 Rat
FunctionThis gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Related PathwayDruggable Genome B cell receptor signaling pathwayPrimary immunodeficiency

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample (30 ug of whole cell lysate). A: Hela. 10% SDS PAGE. TA308826 diluted at 1:500.
IF Image
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using B-cell linker protein(TA308826) antibody at 1:200 dilution.

 

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