Home Antibody All anti-BLNK antibodies
Also for BLNK (NM_001114094)
|Synthetic peptide corresponding to a region within amino acids 394 and 456 of BLNK (Uniprot ID#Q8WV28)|
|Human (Predicted: Mouse, Rat, Bovine)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Mouse (100%), Rat (100%), Bovine (100%)
|Homo sapiens B-cell linker (BLNK), transcript variant 2|
|AGM4; BASH; bca; BLNK-S; LY57; SLP-65; SLP65|
Entrez Gene 29760 Human
Entrez Gene 17060 Mouse
Entrez Gene 499356 Rat
|This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Druggable Genome B cell receptor signaling pathwayPrimary immunodeficiency|
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Sample (30 ug of whole cell lysate). A: Hela. 10% SDS PAGE. TA308826 diluted at 1:500.
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using B-cell linker protein(TA308826) antibody at 1:200 dilution.