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Home Antibody All anti-BIRC5 antibodies

Anti-BIRC5 CONJUGATED Antibody clone 2D9

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA400023
  • Anti-BIRC5/Survivin mouse mAb, clone 2D9, DyLight488 conjugated
100 ul 325 In Stock
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FC(1)
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Also for BIRC5 (NM_001168)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human BIRC5 (NP_001159) produced in HEK293T cell.
Clone Nameclone 2D9 IsotypeIgG1
Species ReactivityHuman Concentration0.49mg/ml
Guaranteed Application *FC Suggested DilutionsFC: 1:100
BufferHuman
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens baculoviral IAP repeat containing 5 (BIRC5), transcript variant 1
Alternative NameAPI4; EPR-1
Database LinkNP_001159
FunctionThis gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined.
Related Pathway
Apoptosis
Cell cycle

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FC Image
HEK293T cells were transfected with pCMV6-ENTRY control (PS01, left panel) or BIRC5 cDNA (right panel) and incubated for 48 hours after transfection. The cells were detached, fixed with 2% formaldehyde for 30 min, permeabilized with 0.1% trixon-X100, and then stained with DyLight488-labeled BIRC5 antibodies (TA400023).

 

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