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Also for BIRC5 (NM_001012270)
|Survivin antibody was raised against a peptide corresponding to amino acids near the carboxy-terminus of human survivin.|
||ELISA, WB: 1 ug/ml, ICC: 10 ug/ml, IF: 10 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens baculoviral IAP repeat containing 5 (BIRC5), transcript variant 2|
Entrez Gene 332 Human
|Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP (1-3). Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas (1,3).|
|Stem cell - PluripotencyDruggable Genome Pathways in cancerColorectal cancer|
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Western blot analysis of survivin in MOLT4 cell lysate in the absence (A) or presence (B) of blocking peptide with survivin antibody at 1 ug/mL.
Immunocytochemistry staining of MOLT4 cells using survivin at 10 ug/mL.