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Home Antibody All anti-BIRC5 antibodies

Anti-BIRC5 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306026
  • Rabbit Polyclonal Survivin Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC423314) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for BIRC5 (NM_001012270)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenSurvivin antibody was raised against a peptide corresponding to amino acids near the carboxy-terminus of human survivin.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, ICC: 10 ug/ml, IF: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens baculoviral IAP repeat containing 5 (BIRC5), transcript variant 2
Alternative NameAPI4; EPR-1
Database LinkNP_001012270
Entrez Gene 332 Human
FunctionApoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP (1-3). Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas (1,3).
Related PathwayStem cell - PluripotencyDruggable Genome Pathways in cancerColorectal cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of survivin in MOLT4 cell lysate in the absence (A) or presence (B) of blocking peptide with survivin antibody at 1 ug/mL.
IF Image
Immunocytochemistry staining of MOLT4 cells using survivin at 10 ug/mL.

 

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