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Home Antibody All anti-BIRC5 antibodies

Anti-BIRC5 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301429
  • Rabbit Polyclonal Antibody against Survivin [Ser20]
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400469) , 20ug
100ul $325 3-7 Days
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WB(1)
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Also for BIRC5 (NM_001168)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide surrounding the phosphorylated serine 20 of the human Survivin protein. [Swiss-Prot #O15392]
Clone Name IsotypeIgG
Species Reactivityhuman Concentration1.25 mg/ml
Guaranteed Application *WB Suggested DilutionsWB:3 ug/ml
BufferPBS, 30% Glycerol and 0.1% sodium azide
Purification peptide affinity purified

Reference Data

Target NameHomo sapiens baculoviral IAP repeat containing 5 (BIRC5), transcript variant 1
Alternative NameAPI4; EPR-1
Database LinkNP_001159
FunctionSurvivin is a structurally unique inhibitor of apoptosis (IAP) that has been linked to protection from apoptosis, control of cell division, and cellular adaptation to stress. In order for survivin to provide this cytoprotection an interaction with at least one other IAP, such as XIAP, is necessary. It has recently been shown that Survivin is phosphorylated at Ser20 by protein kinase A (PKA) in the cytosol but not in the mitochondria. This phosphorylation on Ser20 disrupts the binding of cytosolic survivin to XIAP and therefore diminishes survivin's cytoprotective properties.
Related Pathway
Apoptosis
Cell cycle

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WB Image
Detection of Survivin [Ser20] in phosphorylated recombinant protein (+), but not in unphosphorylated protein (-)

 

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