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Home Antibody All anti-BIRC5 antibodies

Anti-BIRC5 Antibody 60.11

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA301425 Mouse Monoclonal Antibody against Survivin (60.11) - Astrocyte Marker 100ul $325 3-7 Days
LC400469 BIRC5 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
FC(1)
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Also for BIRC5 (NM_001168)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenFull-length recombinant human survivin.
Clone Name60.11 IsotypeIgG2a kappa
Species Reactivityhuman, mouse, rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, FC Suggested DilutionsWB: 1: 1000
Buffer0.01M Na phosphate, 0.25M NaCl [pH 7.6], and 15 mg/ml BSA, 0.01% Thimerisol and 0.05% sodium azide
Purification Ascites

Reference Data

Target NameHomo sapiens baculoviral IAP repeat containing 5 (BIRC5), transcript variant 1
Alternative NameAPI4; EPR-1
Database LinkNP_001159
Entrez Gene 332 Human
Entrez Gene 11799 Mouse
Entrez Gene 64041 Rat
FunctionRegulated inhibition of programmed cell death (apoptosis) preserves normal homeostasis and tissue and organ morphogenesis. Aberrations in this process contribute to human diseases and cancer by abnormally prolonging cell viability. Recently, several apoptosis inhibitors related to the baculovirus iap gene have been found in various species, including human. IAP proteins contain one/three Cys/His baculovirus IAP repeats plus a C-terminal RING finger and are thought to block an evolutionary conserved step in apoptosis. Survivin encodes a structurally unique inhibitor of apoptosis (IAP). Survivin expression is turned off during fetal development and is not found in non-neoplastic adult human tissues. Survivin becomes abundantly re-expressed in transformed cells and in all of the most common cancers of lung, colon, pancreas, breast and prostate in vivo. Survivin appears to be situated at the crossroads of cell death and cell division, governing a checkpoint involved in cytokinesis while also suppressing apoptosis. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affect regulation of neural cell proliferative responses after brain injury.
Related PathwayStem cell - PluripotencyDruggable Genome Pathways in cancerColorectal cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Survivin detected in rat aorta smooth muscle cell lysate
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Flow Cytometry: Staining of NTERA-2 cells using Survivin Antibody at a 1:2000 dilution detected using Dylight-488 conjugated goat anti-mouse IgG secondary antibody.
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