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Home Antibody All anti-BIRC2 antibodies

Anti-BIRC2 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306169 Rabbit Polyclonal cIAP Antibody 100ug $325 3-7 Days
LC400468 BIRC2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for BIRC2 (NM_001166)
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OriGene Data

Immunogenc-IAP antibody was raised against a synthetic peptide corresponding to 14 amino acids at the C-terminus of human c-IAP1 c-IAP antibody detects both c-IAP1 and c-IAP2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 - 4 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens baculoviral IAP repeat containing 2 (BIRC2), transcript variant 1
Alternative NameAPI1; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB; RNF48
Database LinkNP_001157
Entrez Gene 329 Human
Entrez Gene 11797 Mouse
FunctionApoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases (1 for review). The two isoforms of c-IAP (c-IAP1 and c-IAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases–3, –7, (2,3). The c-IAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF-alpha by its receptor (2,4). Omi, a negative regulator of c-IAP, inhibits its activity by catalytically cleaving c-IAP (5). Another negative regulator, Smac/DIABLO, acts by enhancing the auto-ubiquitization activity of c-IAP (6).
Related PathwayDruggable Genome Ubiquitin mediated proteolysisApoptosisFocal adhesionNOD-like receptor signaling pathwayPathways in cancerSmall cell lung cancerMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of c-IAP in human lung lysate with c-IAP antibody at 1 (lane A), 2 (lane B), and 4 (lane C) ug/ml, respectively.

IHC Image
Immunohistochemistry of cIAP in human lung cells with cIAP antibody at 10 ug/ml.

IF Image
Immunofluorescence of cIAP in Human Lung cells with cIAP antibody at 20 ug/mL.


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