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Home Antibody All anti-BIRC2 antibodies

Anti-BIRC2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306169
  • Rabbit Polyclonal cIAP Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400468) , 20ug
100ug $325 3-7 Days
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WB(1)
IHC(1)
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Also for BIRC2 (NM_001166)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

Immunogenc-IAP antibody was raised against a synthetic peptide corresponding to 14 amino acids at the C-terminus of human c-IAP1 c-IAP antibody detects both c-IAP1 and c-IAP2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens baculoviral IAP repeat containing 2 (BIRC2), transcript variant 1
Alternative NameAPI1; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB; RNF48
Database LinkNP_001157
FunctionApoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases (1 for review). The two isoforms of c-IAP (c-IAP1 and c-IAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases–3, –7, (2,3). The c-IAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF-alpha by its receptor (2,4). Omi, a negative regulator of c-IAP, inhibits its activity by catalytically cleaving c-IAP (5). Another negative regulator, Smac/DIABLO, acts by enhancing the auto-ubiquitization activity of c-IAP (6).
Related Pathway
Apoptosis
Focal Adhesion

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WB Image
Western blot analysis of c-IAP in human lung lysate with c-IAP antibody at 1 (lane A), 2 (lane B), and 4 (lane C) ug/ml, respectively.
IHC Image
Immunohistochemistry of cIAP in human lung cells with cIAP antibody at 10 ug/ml.

 

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