Home Antibody All anti-BID antibodies
|Bid antibody was raised against a peptide corresponding to 14 amino acids near the carboxy-terminus of human Bid.|
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Ion exchange chromatography purified (Protein A or G Sepharose)
|Homo sapiens BH3 interacting domain death agonist (BID), transcript variant 2|
|Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death (reviewed in 2 and 3). Bid, a pro-apoptotic Bcl-2 family member, is cleaved by caspase-8 in response to apoptotic signals (4,5), exposing the Bcl-2 homology 3 (BH3) domain which is normally buried in the full-length protein (6). The cleaved complex is myris-toylated and translocated to the mitochondrial membrane where it may induce mitochondrial Bax and Bak to oligomerize (7,8).|
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Western blot analysis of Bid in mouse lung cell lysates with Bid antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
Immunohistochemical staining of mouse lung tissue using Bid antibody at 2 ug/ml.