Home Antibody All anti-BICD2 antibodies
Also for BICD2 (NM_001003800)
|BICD2 antibody was raised against a 14 amino acid peptide from near the center of human BICD2.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens bicaudal D homolog 2 (Drosophila) (BICD2), transcript variant 1|
Entrez Gene 23299 Human
Entrez Gene 76895 Mouse
Entrez Gene 306809 Rat
|BICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. Similar to the highly homologous protein BICD1, BICD2 can bind to dynein-dynactin complex, primarily through the dynamitin subunit of dynactin. The C-terminus of BICD2 targets the protein to the Golgi complex while the N-terminal domain of BICD2 co-immunoprecipitates with cytoplasmic dynein, suggesting BICD2 plays a role in the dynein-dynactin interaction on the surface of membranous organelles. Mice engineered to overexpress the BICD2 amino terminal domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation, neurofilament swelling in proximal axons, etc., suggesting that impaired dynein/dynactin function may explain some of the pathological features observed in ALS patients. This BICD2 antibody will not cross-react with BICD1.|
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Western blot analysis of BICD2 in A549 cell lysate with BICD2 antibody at (A) 1 and (B) 2 µg/ml.