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Home Antibody All anti-BEST1 antibodies

Anti-BEST1 Antibody


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SKU Description Amount Price Availability*  
TA323887 Anti-BEST1 Rabbit Polyclonal Antibody 100ul 325
2-3 Weeks
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OriGene Data

ImmunogenSynthetic peptide corresponding to a region derived from 438-452 amino acids of human bestrophin 1
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.6mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsELISA: 1:1000-2000, WB: 1:200-1000, IHC: 1:25-100
Predicted MW Explanation 68kDa
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens bestrophin 1 (BEST1), transcript variant 2
Alternative NameARB; BEST; BMD; RP50; TU15B; VMD2
Database LinkNP_001132915
Entrez Gene 7439 Human
Entrez Gene 24115 Mouse
Entrez Gene 293735 Rat
FunctionThis gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2); also known as Best macular dystrophy; in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.
Related PathwayIon Channels: OtherTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Predicted band size: 68 kDa . Positive control: Mouse eyes tissue lysate. Recommended dilution: 1/200-1000

IHC Image
Predicted cell location: Cytoplasm. Positive control: Human ovarian cancer tissue. Recommended dilution: 1/25-100 The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using BEST1 antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification: x200)


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