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Home Antibody All anti-BECN1 antibodies

Anti-BECN1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301471
  • Rabbit Polyclonal Antibody against Beclin 1
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401239) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for BECN1 (NM_003766)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenNB 500-266 was raised against full length human beclin 1 protein.
Clone Name IsotypeIgG
Species Reactivityhuman, mouse Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:500
Buffer0.1% sodium azide
Purification Whole antisera

Reference Data

Target NameHomo sapiens beclin 1, autophagy related (BECN1)
Alternative NameATG6; beclin1; VPS30
Database LinkNP_003757
FunctionBeclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic-lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl-2-binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 60 kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons. In gene transfer studies, beclin 1 promotes nutrient deprivation-induced autophagy, inhibits mammary tumorigenesis, and inhibits viral replication. Expression of the Beclin 1 protein is frequently decreased in malignant breast epithelial cells. Based upon these observations, it is speculated that beclin 1 may work through induction of autophagy to negatively regulate tumorigenesis and to control viral infections. Beclin 1 may also play a role in other biologic processes in which autophagy is important such as cell differentiation and nutritional stress responses.
Related Pathway
Senescence and Autophagy

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WB Image
Detection of Beclin 1 in liver lysates. Lane 1 mouse liver, Lane 2 human liver

 

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