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Home Antibody All anti-BECN1 antibodies

Anti-BECN1 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA301471 Rabbit Polyclonal Antibody against Beclin 1 100ul $325 3-7 Days
LC401239 BECN1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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WB(1)
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Also for BECN1 (NM_003766)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenNB 500-266 was raised against full length human beclin 1 protein.
Clone Name IsotypeIgG
Species Reactivityhuman, mouse ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500
Buffer0.1% sodium azide
Purification Whole antisera

Reference Data

Target NameHomo sapiens beclin 1, autophagy related (BECN1)
Alternative NameATG6; beclin1; VPS30
Database LinkNP_003757
Entrez Gene 8678 Human
Entrez Gene 56208 Mouse
FunctionBeclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic-lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl-2-binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 60 kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons. In gene transfer studies, beclin 1 promotes nutrient deprivation-induced autophagy, inhibits mammary tumorigenesis, and inhibits viral replication. Expression of the Beclin 1 protein is frequently decreased in malignant breast epithelial cells. Based upon these observations, it is speculated that beclin 1 may work through induction of autophagy to negatively regulate tumorigenesis and to control viral infections. Beclin 1 may also play a role in other biologic processes in which autophagy is important such as cell differentiation and nutritional stress responses.
Related PathwayDruggable Genome Regulation of autophagy

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Detection of Beclin 1 in liver lysates. Lane 1 mouse liver, Lane 2 human liver
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