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Anti-BCR Antibody EP535Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303403
  • Rabbit monoclonal antibody against Bcr (C-term)(EP535Y)
100ul $325 3-7 Days
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IHC(1)
IF(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the C-term of human Bcr was used as immunogen.
Clone NameEP535Y IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *IHC, IF Suggested DilutionsWB: 1:2000 - 1:10000; IHC-P: Use at an assay dependent dilution; ICC: 1:100 - 1:250; FC: 1:20; IP: 1:60
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens breakpoint cluster region (BCR), transcript variant 1
Alternative NameALL; BCR1; CML; D22S11; D22S662; PHL
Database LinkNP_004318
FunctionA reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Related Pathway

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IHC Image
Immunohistochemistry (Paraffin-embedded sections) - Bcr antibody [EP535Y]; TA303403, staining human lymphoma by immunohistochemistry, paraffin embedded tissue.
IF Image
Immunocytochemistry/ Immunofluorescence - Bcr antibody [EP535Y]; TA303403, staining HeLa cells by immunofluorescence.

 

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