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Home Antibody All anti-BCL2L11 antibodies

Anti-BCL2L11 Antibody Y36

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA303860 Rabbit monoclonal antibody against Bim(Y36) 100ul $325 In Stock
LC416580 BCL2L11 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(2)
IHC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the exons 2 of human Bim was used as immunogen. The antibody can recognize all isoforms of Bim. The antibody does not cross-react with other Bcl-2 family members.
Clone NameY36 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500; IHC: 1:100; ICC: 1:100; IP: 1:40
Predicted MW Explanation 22 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification IgG fraction
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens BCL2-like 11 (apoptosis facilitator) (BCL2L11), transcript variant 6
Alternative NameBAM; BIM; BOD
Database LinkNP_006529
Entrez Gene 10018 Human
FunctionThe protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq].
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Bim antibody [Y36]; Anti-Bim antibody [Y36] at 1/500 dilution + A431 cell lysate.Predicted band size : 22 kDa.Observed band size : 22 kDa.
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Western blot - Bim antibody [Y36]; Anti-Bim antibody [Y36] at 1/500 dilution + Whole cell lysates prepared from human jurkat cells at 200000 cells.Secondary.HRP conjugated Donkey polyclonal to rabbit IgG at 1/2000 dilution.developed using the ECL technique.Performed under reducing conditions.Predicted band size : 22 kDa.Observed band size : 22 kDa.Exposure time : 30 seconds
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Immunohistochemistry (Paraffin-embedded sections) - Bim antibody [Y36]; Immunohistochemical analysis of paraffin-embedded breast carcinoma using TA303860 at 1/100 dilution.
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