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Anti-BCL2L11 Antibody Y36

* Buy one primary antibody, get 50% off a GAPDH loading control antibody.

WB(1)

IHC(1)

OriGene Data

Immunogen	A synthetic peptide corresponding to residues in the exons 2 of human Bim was used as immunogen. The antibody can recognize all isoforms of Bim. The antibody does not cross-react with other Bcl-2 family members.
Clone Name	Y36	Isotype	Rabbit IgG
Species Reactivity	Human	Concentration
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB: 1:500; IHC: 1:100; ICC: 1:100; IP: 1:40
Buffer	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens BCL2-like 11 (apoptosis facilitator) (BCL2L11), transcript variant 6
Alternative Name	BAM; BIM; BOD
Database Link	NP_006529
Function	The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq].
Related Pathway	Apoptosis

Related Lysate from OriGene • Transient overexpression lysate of BCL2-like 11 (apoptosis facilitator) (BCL2L11), transcript variant 6 Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • BCL2L11 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • BCL2L11 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Bcl2l11 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • BCL2L11 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Bcl2l11 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens BCL2-like 11 (apoptosis facilitator) (BCL2L11), transcript variant 6 as transfection-ready DNA • Lenti ORF clone of Human BCL2-like 11 (apoptosis facilitator) (BCL2L11), transcript variant 6, mGFP tagged • Lenti ORF clone of Human BCL2-like 11 (apoptosis facilitator) (BCL2L11), transcript variant 6 , Myc-DDK-tagged • GFP-tagged ORF clone of Homo sapiens BCL2-like 11 (apoptosis facilitator) (BCL2L11), transcript variant 6 as transfection-ready DNA Related cDNA Clones • ORIGENE UNIQUE VARIANT 1 of Homo sapiens BCL2-like 11 (apoptosis facilitator) (BCL2L11), as transfection-ready DNA • Homo sapiens BCL2-like 11 (apoptosis facilitator) (BCL2L11), transcript variant 6 as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)