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Home Antibody All anti-BCL2 antibodies

Anti-BCL2 Antibody E17


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA303400 Rabbit monoclonal antibody against Bcl-2(E17) 100ul $325 In Stock
LC424602 BCL2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues between BH3 and BH4 of human Bcl-2 was used as immunogen. The antibody does not cross-react with other Bcl-2 family members.
Clone NameE17 IsotypeIgG
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, Assay, IHC, FC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: Use at an assay dependent dilution; ICC/IF: 1:200; FC: 1:200; IP: 1:50
Predicted MW Explanation 26 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification IgG fraction
Note Does not react with Rat

Reference Data

Target NameHomo sapiens B-cell CLL/lymphoma 2 (BCL2), transcript variant alpha
Alternative NameBcl-2; PPP1R50
Database LinkNP_000624
Entrez Gene 596 Human
Entrez Gene 12043 Mouse
FunctionThis gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq].
Related PathwayES Cell Differentiation/IPSTransmembraneStem cell - PluripotencyDruggable Genome ApoptosisFocal adhesionNeurotrophin signaling pathwayAmyotrophic lateral sclerosis (ALS)Pathways in cancerColorectal cancerMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Bcl2 antibody [E17]; Anti-Bcl-2 antibody [E17] at 1/1000 dilution + Jurkat cell lysate .Predicted band size : 26 kDa.Observed band size : 26 kDa.

Assay Image
Other-Anti-Bcl2 antibody [E17](TA303400); Equilibrium disassociation constant (KD)..

IHC Image
Immunohistochemistry (Paraffin-embedded sections) - Bcl2 antibody [E17]; Immunohistochemical analysis of paraffin-embedded human breast carcinoma using TA303400 at 1/200 dilution.

IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bcl2 antibody [E17]; TA303400 showing positive staining in Lung adenocarcinoma tissue.

IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bcl2 antibody [E17]; TA303400 showing positive staining in B cell lymphoma tissue.

IHC Image
IHC of Human salivary glands taken from patients with primary Sj?gren's syndrome, staining Bcl2 with TA303400. Antigen retrieval was performed via heat mediation in a citrate buffer (pH 6). Sections were blocked using 2% BSA, 10% normal serum and permeabilized with 0.5% Triton X-100. Samples were incubated with primary antibody 1:100 for one hour at RT. An AlexaFluor?594-conjugated anti-rabbit IgG was used as the secondary antibody.

FC Image
Flow Cytometry-Anti-Bcl2 antibody(TA303400); Overlay histogram showing Jurkat cells stained with TA303400 (red line). The secondary antibody used was DyLight 488 goat anti-rabbit IgG (H+L) at 1:500. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1ug/1x10^6 cells) used under the same conditions. This antibody gave a positive signal in Jurkat cells under the same conditions.


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