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Home Antibody All anti-BCL10 antibodies

Anti-BCL10 CONJUGATED Antibody clone 4A8

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA400004
  • Anti-BCL10 mouse mAb, clone 4A8, PE conjugated
100 ul 325 In Stock
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FC(1)

OriGene Data

ImmunogenFull length human recombinant protein of human BCL10 (NP_003912) produced in HEK293T cell.
Clone Nameclone 4A8 IsotypeIgG1
Species ReactivityHuman Concentration0.5mg/ml
Guaranteed Application *FC Suggested DilutionsFC:1:50
BufferHuman
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens B-cell CLL/lymphoma 10 (BCL10)
Alternative Namec-E10; CARMEN; CIPER; CLAP; mE10
Database LinkNP_003912
FunctionThis gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Related Pathway

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FC Image
Jurkat T cells are fixed 2% formaldehyde for 20 min, then permeabilized with 0.1% saponin. The cells are then stained with a PE-labeled isotope control antibody, or 4A8 or 6A4 anti-Bcl10 antibodies.

 

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