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Anti-BCL10 Antibody EPR3175


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against Bcl-10(clone EPR3175)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418351) , 20ug Explanation
100ul 325 3-7 Days
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Also for BCL10 (NM_003921)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human EN1 was used as an immunogen.
Clone NameEPR3175 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsICC/IF: 1:100 - 1:250; WB: 1:1000 - 1:10000; IP: 1:10 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt or IHC-P.

Reference Data

Target NameHomo sapiens B-cell CLL/lymphoma 10 (BCL10)
Alternative Namec-E10; CARMEN; CIPER; CLAP; mE10
Database LinkNP_003912
Entrez Gene 8915 Human
FunctionBcl-10 is an adaptor protein with a caspase recruitment domain (CARD) that promotes apoptosis and activates pro-caspase 9 and NF-kB (1, 2). Bcl-10 also interacts with other CARD domain containing proteins including CARD9, 10, 11 and 14. Bcl-10 is found to form a complex with MALT1, a protein known to be translocated in MALT lymphomas. Bcl-10 and MALT1 play a critical role in antigen receptor-mediated lymphocyte proliferation and signaling to NF-B, which controls the expression of genes critical for cell survival, proliferation, and immune responses (3,4). Defects in Bcl-10 have been identified in various types of cancer.
Related PathwayDruggable Genome T cell receptor signaling pathwayB cell receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Bcl10 antibody [EPR3175]; All lanes : Anti-Bcl10 antibody [EPR3175] at 1/1000 dilution.Lane 1 : Daudi cell lysate.Lane 2 : Raji cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : HuT-78 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 26 kDa.
IF Image
Immunocytochemistry/ Immunofluorescence - Bcl10 antibody [EPR3175]; TA307332, at 1/100 dilution, staining Bcl10 in HeLa cells by Immunofluorescence.


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