Home Antibody All anti-BCL10 antibodies
Also for BCL10 (NM_003921)
|Bcl10 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human Bcl10.|
|Human, Mouse, Rat
||ELISA, WB: 0.5 ug/ml, ICC: 1 ug/ml, IF: 10 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens B-cell CLL/lymphoma 10 (BCL10)|
|c-E10; CARMEN; CIPER; CLAP; mE10|
Entrez Gene 8915 Human
Entrez Gene 12042 Mouse
Entrez Gene 83477 Rat
|Apoptosis is related to many diseases including cancer. Cell death signals are transduced by death domain (DD) and caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include ARC, RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD containing protein was recently identified by several groups and designated Bcl10, CIPER, mE10, CARMEN, CLAP. Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF-kappaB activation. Bcl10 interacts with caspase-9 and enhances pro-caspase-9 processing (3) and induces apoptosis through caspase-9 activation . Bcl10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas indicating that it may be commonly involved in the pathogenesis of human malignancy . Bcl10 is expressed in many human and murine tissues and cell lines.|
|Druggable Genome T cell receptor signaling pathwayB cell receptor signaling pathway|
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Western blot analysis of Bcl-10 in Raji whole cell lysate in the absence (A) or presence (B) of peptide (2161P) with Bcl-10 antibody at 1:500 dilution.
Immunocytochemistry of Bcl10 in Raji cells with Bcl10 antibody at 1 ug/mL.