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Home Antibody All anti-BCAS3 antibodies

Anti-BCAS3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306933
  • Rabbit Polyclonal BCAS3 Antibody
100ug 325 3-7 Days
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WB(1)
IHC(1)
IF(1)

OriGene Data

ImmunogenBCAS3 antibody was raised against an 18 amino acid peptide near the amino terminus of human BCAS3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 0.5 - 1 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens breast carcinoma amplified sequence 3 (BCAS3), transcript variant 1
Alternative NameGAOB1; MAAB
Database LinkNP_001092902
Entrez Gene 54828 Human
Entrez Gene 192197 Mouse
Entrez Gene 363662 Rat
FunctionThe Breast carcinoma amplified sequence (BCAS3) gene is localized to 17q23, a region that is often amplified in breast cancers. Copy number gains at this region have also been reported in other tumors such as brain, lung, liver, testis and bladder. BCAS3 is thought to be an estrogen receptor (ER)-a co-activator that acts through PELP1, another ER-a that in turn activates BCAS3 expression. This may set up a positive feedback loop leading to ER-a signal amplification in the cell which may play a significant role in breast cancer. BCAS3 expression has also been observed in embryonic stem cells and vascular precursors, suggesting that it may also play a role in embryogenesis and tumor angiogenesis.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of BCAS3 in rat brain tissue lysate with BCAS3 antibody at (A) 0.5 and (B) 1 ug/mL.
IHC Image
Immunohistochemistry of BCAS3 in human breast carcinoma with BCAS3 antibody at 5 ug/mL.
IF Image
Immunofluorescence of BCAS3 in human breast carcinoma tissue with BCAS3 antibody at 20 ug/mL.

 

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