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Anti-BCAS2 Antibody EPR4375
Also for BCAS2 (NM_005872)
|A synthetic peptide corresponding to residues in human BCAS2 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; ICC/IF: 1:250 - 1:500
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt or IHC-P.
|Homo sapiens breast carcinoma amplified sequence 2 (BCAS2)|
|DAM1; Snt309; SPF27|
|BCAS2 (Breast carcinoma-amplified sequence 2), also known as pre-mRNA-splicing factor SPF27, is a ubiquitously expressed protein that was initially identified as overexpressed and amplified in breast cancer cell lines (1). It is a component of the spliceosome and is involved in mRNA splicing (1, 2). BCAS2 interacts with estrogen receptor (ER) beta, TR beta, PR, and PPAR gamma in a ligand-independent way (1). BCAS2 has been reported to be a transcriptional coactivator of estrogen receptor and a novel negative regulator of p53 (3). Thus, BCAS2 might play an important role in breast cancer development and potentially become a molecular target for cancer therapy (1).|
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Western blot - BCAS2 antibody [EPR4375]; All lanes : Anti-BCAS2 antibody [EPR4375] at 1/1000 dilution.Lane 1 : SH-SY5Y cell lysate.Lane 2 : MCF7 cell lysate.Lane 3 : Neuro-2a cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 26 kDa.
Immunocytochemistry/ Immunofluorescence - BCAS2 antibody [EPR4375]; Immunofluorescent staining of HeLa cells using ab108330 at a dilution of 1/250.