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Home Antibody All anti-BCAS2 antibodies

Anti-BCAS2 Antibody EPR4376

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA307187
  • Rabbit monoclonal antibody against BCAS2(clone EPR4376)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417014) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for BCAS2 (NM_005872)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human BCAS2 was used as an immunogen.
Clone NameEPR4376 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100
Predicted MW Explanation 26 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IHC-P.

Reference Data

Target NameHomo sapiens breast carcinoma amplified sequence 2 (BCAS2)
Alternative NameDAM1; Snt309; SPF27
Database LinkNP_005863
Entrez Gene 10286 Human
Entrez Gene 68183 Mouse
Entrez Gene 295334 Rat
FunctionBCAS2 (Breast carcinoma-amplified sequence 2), also known as pre-mRNA-splicing factor SPF27, is a ubiquitously expressed protein that was initially identified as overexpressed and amplified in breast cancer cell lines (1). It is a component of the spliceosome and is involved in mRNA splicing (1, 2). BCAS2 interacts with estrogen receptor (ER) beta, TR beta, PR, and PPAR gamma in a ligand-independent way (1). BCAS2 has been reported to be a transcriptional coactivator of estrogen receptor and a novel negative regulator of p53 (3). Thus, BCAS2 might play an important role in breast cancer development and potentially become a molecular target for cancer therapy (1).
Related Pathway Spliceosome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-BCAS2 antibody [EPR4376]; All lanes : Anti-BCAS2 antibody [EPR4376] at 1/1000 dilution.Lane 1 : SH-SY5Y cell lysate .Lane 2 : MCF-7 cell lysate .Lane 3 : SKBR-3 cell lysate .Lane 4 : C6 cell lysate .Lane 5 : PC-12 cell lysate .Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 26 kDa.

 

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