Home Antibody All anti-BCAR3 antibodies
Also for BCAR3 (NM_003567)
|Peptide with sequence C-RKLEPPPVKQAEL, from the C Terminus of the protein sequence according to NP_003558.1.|
|Test: Mouse. Expected from seq similarity: Human, Dog, Pig, Cow
|0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20C. Minimize freezing and thawing.
|Homo sapiens breast cancer anti-estrogen resistance 3 (BCAR3), transcript variant 2|
Entrez Gene 8412 Human
Entrez Gene 29815 Mouse
Entrez Gene 479941 Dog
|Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. [provided by RefSeq]. |
|Druggable Genome |
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TA305647 (0.5ug/ml) staining of Mouse Kidney epithelial cells lysate (15ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.