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Home Antibody All anti-BCAR1 antibodies

Anti-BCAR1 PHOSPHO Antibody EPR1860

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307102
  • Rabbit monoclonal antibody against p130Cas Phospho (pY410) (clone EPR1860 ) (Phospho-Specific)
100ul 325 3-7 Days
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WB(1)
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Also for BCAR1 (NM_014567)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues surrounding Tyrosine 410 of human p130Cas was used as an immunogen.
Clone NameEPR1860 IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsIP: 1:50, WB: 1:2,500 - 5,000,
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 6
Alternative NameCAS; CAS1; CASS1; CRKAS; P130Cas
Database LinkNP_055382
FunctionBreast cancer anti-estrogen resistance protein 1 (p130Cas) is a docking protein that plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (1). It has defined function in cardiovascular development, actin filament assembly and Src-induced transformation (2). p130Cas is highly phosphorylated at tyrosines during transformation by v-Src, as well as by v-Crk, forming stable complexes with these oncoproteins. Cytoplasmic p130Cas has been shown to move to the membrane upon tyrosine phosphorylation. p130Cas is a common cellular target of phosphorylation signal via v-Crk and v-Src oncoproteins, and its unique structure indicates its possible role in assembling signals from multiple SH2-containing molecules (3). It is implicated in induction of cell migration, and over expression of p130Cas confers anti-estrogen resistance on breast cancer cells (1).
Related Pathway
EGFR1 Signaling Pathway
Focal Adhesion
Hemostasis

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WB Image
Western blot - BCAR1 (phospho Y410) antibody [EPR1860]; All lanes : Anti-BCAR1 (phospho Y410) antibody [EPR1860] at 1/2500 dilution.Lane 1 : HeLa cell lysate untreated.Lane 2 : HeLa cell lysate treated with pervanadate.Lysates/proteins at 10 µg per lane.Secondary.HRP-labeled goat anti-rabbit at 1/2000 dilution.Predicted band size : 93 kDa.

 

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