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Home Antibody All anti-BBC3 antibodies

Anti-BBC3 Antibody 10C5G1

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319891
  • Mouse PUMA Monoclonal Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC402330) , 20ug
100ug $325 3-7 Days
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WB(1)
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Also for BBC3 (NM_001127240)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRecombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.
Clone Name10C5G1 IsotypeIgG1
Species ReactivityHuman, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsELISA, WB: 2.5 - 5 ug/ml
BufferPUMA Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Purification PUMA Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Reference Data

Target NameHomo sapiens BCL2 binding component 3 (BBC3), transcript variant 1
Alternative NameJFY-1; JFY1; PUMA
Database LinkNP_001120712
FunctionPUMA Monoclonal Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAα and PUMAβ. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
Related Pathway
Apoptosis

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of PUMA expression in K562 cell lysate with PUMA antibody at (A) 2.5 and (B) 5 ug/mL.

 

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