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Home Antibody All anti-BBC3 antibodies

Anti-BBC3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301519
  • Rabbit Polyclonal Antibody against PUMA
  • FREE positive control: HEK293T cell transient overexpression lysate (LC402330) , 20ug
100ul $325 3-7 Days
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WB(1)
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Also for BBC3 (NM_014417)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide made to a region within the C-terminus of the human PUMA protein sequence (between residues 150-193).
Clone Name IsotypeIgG
Species Reactivityhuman Concentration5.65 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 2-4 ug/ml
Buffer

Reference Data

Target NameHomo sapiens BCL2 binding component 3 (BBC3), transcript variant 4
Alternative NameJFY-1; JFY1; PUMA
Database LinkNP_055232
FunctionA novel gene PUMA (p53 upregulated modulator of apoptosis) is a target for activation by the p53 tumor-suppressor gene. p53 functions as a transcriptional activator, and influences p53-inducible genes that play a role in the induction of apoptosis in response to p53. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
Related Pathway
Apoptosis

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WB Image
Detection of the beta isoform of PUMA in HL-60 whole cell lysate (4 ug/ml). ECL detection at a 30 minute exposure.

 

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