Home Antibody All anti-BAX antibodies
|Bax antibody was raised against a peptide corresponding to 16 amino acids near the amino-terminus of human Bax.|
||ELISA, WB: 1 - 4 ug/ml, ICC: 2 ug/ml, IF: 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Ion exchange chromatography purified (Protein A or G Sepharose)
|Homo sapiens BCL2-associated X protein (BAX), transcript variant beta|
|Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death (reviewed in 2 and 3). Bax, a pro-apoptotic Bcl-2 family member, is a cytosolic protein that changes conformation and translocates to the mitochondria following apoptotic stimuli (4,5). It is thought to share significant functional homology with Bak, another pro-apoptotic Bcl-2 family member, as disruption of bax or bak has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking both show decreased apoptotic capability (6,7).|
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Western blot analysis of Bax in HL-60 cell lysates with Bax antibody at (A) 1, (B) 2, and (C) 4 ug/mL.
Immunocytochemistry staining of HL-60 cells using Bax at 2 ug/mL.