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Anti-BANP Antibody Polyclonal
Also for BANP (NM_001173539)
|BANP antibody was raised against a 14 amino acid synthetic peptide near the center of human BANP.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml, IHC: 10 ug/ml, IF: 20 ug/ml
|BANP Antibody is supplied in PBS containing 0.02% sodium azide.|
|BANP Antibody is affinity chromatography purified via peptide column. (Protein A or G Sepharose)
|Homo sapiens BTG3 associated nuclear protein (BANP), transcript variant 3|
|BEND1; SMAR1; SMARBP1|
|BANP Antibody: BANP was initially identified as a binding protein to BTG3 in a yeast two-hybrid screen. BANP acts as a tumor suppressor by stabilizing p53 expression and leading to cell cycle arrest. p53 in turn binds to upstream elements of the BANP promoter, thereby forming a feedback loop. BANP is down-regulated in advanced stages of human breast cancer, and its overexpression in breast cancer cell lines inhibits their ability to metastasize by modulating TGF-beta signaling. Furthermore, BANP can modulate NF-κB transactivation and can inhibit tumorigenesis by regulating NF-κB target genes. Recent experiments have shown that BANP can also repress HIV-1 LTR mediated transcription by tethering the LTR matrix attachment region to nuclear matrix.|
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Western blot analysis of BANP in mouse kidney tissue lysate with BANP antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of BANP in human kidney tissue with BANP antibody at 10 ug/mL.