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Also for BANF1 (NM_001143985)
|BANF1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human BANF1.|
||ELISA, WB: 0.5 - 1 ug/ml, IF
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens barrier to autointegration factor 1 (BANF1), transcript variant 2|
|BAF; BCRP1; D14S1460; NGPS|
|Barrier-to-autointegration factor 1 (BANF1) is a conserved chromatin protein that non-specifically binds double-stranded DNA. BANF1 also interacts with a family of nuclear proteins that include LAP2, emerin, and MAN1. It is also a host cell component of retroviral pre-integration complexes (PICs), including that of HIV. BANF1 will bind to p55 Gag (the structural precursor of HIV-1 virions) as well as its cleaved product matrix. In addition to being a host cell component of the PIC, it is thought that BANF1 is also present at low levels in incoming virions, and thus might contribute to the assembly or activity of HIV-1 PICs through direct binding to matrix as well as DNA. Despite its predicted molecular weight, BANF1 often migrates at a higher size in SDS-PAGE.|
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Western blot analysis of BANF1 in human kidney tissue lysate with BANF1 antibody at (A) 0.5 and (B) 1 ug/mL.
Immunofluorescence of BANF1 in human kidney tissue with BANF1 antibody at 20 ug/mL.