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Anti-BAG4 Antibody EPR3597
Also for BAG4 (NM_004874)
|A synthetic peptide corresponding to residues in human SODD was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250
|pH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA|
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens BCL2-associated athanogene 4 (BAG4), transcript variant 1|
Entrez Gene 9530 Human
|SODD (BAG4) is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. SODD was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost (1).|
|Druggable Genome |
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Western blot - Anti-Silencer of Death Domain antibody [EPR3597]; All lanes : Anti-Silencer of Death Domain antibody [EPR3597] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : MOLT4 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 50 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Silencer of Death Domain antibody [EPR3597]; Immunohistochemical analysis of paraffin-embedded Human colon adenocarcinoma tissue labelling Silencer of Death Domain with TA307269 at 1/100 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Silencer of Death Domain antibody [EPR3597]; Immunohistochemical analysis of paraffin-embedded Human kidney tissue labelling Silencer of Death Domain with TA307269 at 1/100 dilution.