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Home Antibody All anti-BAG1 antibodies

Anti-BAG1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306338
  • Rabbit Polyclonal BAG-1 Antibody
100ug 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenBAG-1 antibody was raised against a 14 amino acid peptide from near the amino terminus of human BAG-1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens BCL2-associated athanogene (BAG1), transcript variant 1
Alternative NameHAP; RAP46
Database LinkNP_001165886
FunctionBcl-2-associated athanogene 1 (BAG-1) was first identified as an anti-apoptotic bcl-2-binding protein. Later it was found to bind the molecular chaperones Hsp70 and Hsc70 through its carboxy-terminal sequence (termed the Bag domain), resulting in the inhibition of the refolding activity of these chaperones. It is thought that by binding and inhibiting these molecular chaperones, BAG-1is able to modulate the expression level of proteins requiring chaperones to fold correctly. One such group of proteins that are affected is glucocorticoid receptors. Other reports have suggested that the level of BAG-1 expression correlates with the aggressiveness of various cancers. Multiple isoforms of BAG-1 are known to exist.
Related Pathway

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WB Image
Western blot analysis of BAG-1 in PC-3 cell lysate with BAG-1 antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of BAG-1 in human lymph node tissue with BAG-1 antibody at 2 ug/ml.

 

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