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Anti-BAD Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306174 Rabbit Polyclonal BAD Antibody 100ug $325 3-7 Days
LC429193 BAD HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenBad antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human Bad.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 0.5 - 2 ug/mL, ICC: 2 ug/mL, IF: 10 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target NameHomo sapiens BCL2-associated agonist of cell death (BAD), transcript variant 1
Alternative NameBBC2; BCL2L8
Database LinkNP_004313
Entrez Gene 572 Human
Entrez Gene 12015 Mouse
Entrez Gene 64639 Rat
FunctionMembers in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death (reviewed in 1 and 2). Bcl-2 homology 3 (BH3) domain containing pro-apoptotic proteins, such as Bax, Bid, and Bik, form a growing subclass of the Bcl-2 family. Another such protein is the Bcl-2-antagonist of cell death (Bad). Bad regulates apoptosis by forming heterodimers with anti-apoptotic proteins Bcl-2 and Bcl-xL, thereby preventing them from binding with Bax (3). Bad activity is regulated by its phosphorylation; it is inactivated by kinases such as Akt and MAP kinase and thus promotes cell survival (4), whereas JNK-induced phosphorylation promotes the apoptotic role of Bad (5).
Related PathwayDruggable Genome ErbB signaling pathwayApoptosisVEGF signaling pathwayFocal adhesionNeurotrophin signaling pathwayInsulin signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Bad in T24 cell lysates with Bad antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.

IHC Image
Immunohistochemical staining of rat thymus using anti-Bad at 2 ug/ml.

IF Image
Immunofluorescence of BAD in Rat Thymus cells with BAD antibody at 10 ug/mL.


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