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Home Antibody All anti-BACE2 antibodies

Anti-BACE2 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306031 Rabbit Polyclonal BACE2 Antibody 100ug $325 In Stock
LC415975 BACE2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for BACE2 (NM_012105)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenBACE2 antibody was raised against a synthetic peptide corresponding to amino acids 44 to 59 of human BACE2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 ug/mL, ICC: 10 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a
Alternative NameAEPLC; ALP56; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP
Database LinkNP_036237
Entrez Gene 25825 Human
Entrez Gene 56175 Mouse
Entrez Gene 288227 Rat
FunctionAccumulation of the amyloid-beta (alphabeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. alphabeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4-9). BACE2 also cleaves APP at beta-site and at a different site within alphabeta (8). BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region’, suggesting that BACE2 and alphabeta may also contribute to the pathogenesis of Down syndrome (6,7)
Related PathwayTransmembraneProteaseDruggable Genome Alzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of BACE2 in human (A) and mouse (B) heart tissue lysates with BACE2 antibody at 1 ug/ml.

IHC Image
Immunohistochemistry of BACE2 in mouse heart with BACE2 antibody at 10 ug/ml.


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