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Home Antibody All anti-BACE2 antibodies

Anti-BACE2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306031
  • Rabbit Polyclonal BACE2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC415975) , 20ug
100ug 325 In Stock
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WB(1)
IHC(1)
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Also for BACE2 (NM_012105)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenBACE2 antibody was raised against a synthetic peptide corresponding to amino acids 44 to 59 of human BACE2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a
Alternative NameAEPLC; ALP56; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP
Database LinkNP_036237
FunctionAccumulation of the amyloid-beta (alphabeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. alphabeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4-9). BACE2 also cleaves APP at beta-site and at a different site within alphabeta (8). BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region’, suggesting that BACE2 and alphabeta may also contribute to the pathogenesis of Down syndrome (6,7)
Related Pathway

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WB Image
Western blot analysis of BACE2 in human (A) and mouse (B) heart tissue lysates with BACE2 antibody at 1 ug/ml.
IHC Image
Immunohistochemistry of BACE2 in mouse heart with BACE2 antibody at 10 ug/ml.

 

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