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Home Antibody All anti-BACE1 antibodies

Anti-BACE1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306033
  • Rabbit Polyclonal BACE Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC402147) , 20ug
100ug $325 In Stock
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WB(1)
IF(1)
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Also for BACE1 (NM_012104)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenBACE antibody was raised against a peptide corresponding to 17 amino acids at the carboxy terminus of human BACE.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, ICC: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target NameHomo sapiens beta-site APP-cleaving enzyme 1 (BACE1), transcript variant a
Alternative NameASP2; BACE; HSPC104
Database LinkNP_036236
FunctionAccumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor (APP) at b- and g-sites by two proteases. APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-b peptide, which is deposited in the brains of all suffers of Alzheimer’s disease. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.
Related Pathway

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WB Image
Western blot analysis of BACE in human brain tissue lysate in the absence (A) or presence (B) of blocking peptide (2253P) and in mouse 3T3 cell lysate (C) with BACE antibody at 1 ug/mL.
IF Image
Immunocytochemistry of BACE in 3T3 cells with BACE antibody at 10 ug/mL.

 

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