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Also for AXIN1 (NM_003502)
|Synthetic peptide corresponding to a region within amino acids 800 and 862 of AXIN1 (Uniprot ID#O15169)|
|Human (Predicted: Mouse, Rat, Zebrafish, Xenopus laevis, Chicken, Bovine)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Mouse (100%), Rat (100%), Zebrafish (100%), Xenopus laevis (85%), Chicken (92%), Bovine (100%)
|Homo sapiens axin 1 (AXIN1), transcript variant 1|
Entrez Gene 8312 Human
Entrez Gene 12005 Mouse
Entrez Gene 79257 Rat
|This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin (cadherin-associated protein), beta 1, 88kDa, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]|
|Stem cell relevant signaling - Wnt Signaling pathwayES Cell Differentiation/IPSDruggable Genome Wnt signaling pathwayPathways in cancerColorectal cancerEndometrial cancerBasal cell carcinoma|
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Sample(30 ug of whole cell lysate). A:A431. B:H1299. 7.5% SDS PAGE. TA308745 diluted at 1:1500