Home Antibody All anti-ATRX antibodies
Also for ATRX (NM_000489)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 2161 and 2413 of ATRX|
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
||WB:1:500-1:3000; IHC:1:100; IF:1:100-1:200;
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens alpha thalassemia/mental retardation syndrome X-linked (ATRX), transcript variant 1|
|ATR2; JMS; MRXHF1; RAD54; RAD54L; SFM1; SHS; XH2; XNP; ZNF-HX|
Entrez Gene 546 Human
Entrez Gene 22589 Mouse
|The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]|
|Transcription FactorsDruggable Genome |
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Sample (30ug whole cell lysate) A:293T B:HepG2 C:Raji (anti-ATRX antibody diluted at 1:500)
Immunohistochemical analysis of paraffin-embedded A549 xenograft, using ATRX(anti-ATRX antibody) antibody at 1:100 dilution.
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using ATRX(anti-ATRX antibody) antibody at 1:200 dilution.