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Anti-ATRX Antibody

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Specifications Citations (1) Related Products Product Documents
SKU Description Amount Price Availability*  
TA308651 Rabbit Polyclonal antibody to Rad54 (alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)) 100ul $325 In Stock

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WB(2)
IHC(1)
IF(1)

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 2161 and 2443 of Rad54 (Uniprot ID#P46100)
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse (Predicted: Chimpanzee) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 283kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Chimpanzee (100%)

Reference Data

Target NameHomo sapiens alpha thalassemia/mental retardation syndrome X-linked (ATRX), transcript variant 1
Alternative NameATR2; JMS; MRXHF1; RAD54; RAD54L; SFM1; SHS; XH2; XNP; ZNF-HX
Database LinkNP_000480
Entrez Gene 546 Human
Entrez Gene 22589 Mouse
FunctionThe protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
Related PathwayTranscription FactorsDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Rad54 antibody [C3], C-term detects Rad54 protein by western blot analysis. A. 30 ug NIH-3T3 whole cell extract. 5 % SDS-PAGE. Rad54 antibody [C3], C-term (TA308651) dilution: 1:1000
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ATRX antibody detects ATRX protein by western blot analysis. Various whole cell extracts (30 ug) were separated by 5% SDS-PAGE, and the membrane was blotted with ATRX antibody (TA308651) diluted by 1:1000.
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Immunohistochemical analysis of paraffin-embedded A549 xenograft, using ATRX(TA308651) antibody at 1:100 dilution.
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Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using ATRX(TA308651) antibody at 1:200 dilution.
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