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Anti-ATP2A1 Antibody EPR7321
Also for ATP2A1 (NM_004320)
|A synthetic peptide corresponding to residues near the N-terminus of human ATP2A1 was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
|WB, ASSAY, IHC
||WB: 1:10000 - 1:50000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 (ATP2A1), transcript variant a|
Entrez Gene 487 Human
|ATP2A1 is one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and it is involved in muscular excitation and contraction. Mutations in ATP2A1 cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise (1).|
|TransmembraneDruggable Genome Calcium signaling pathwayAlzheimer's disease|
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Western blot - Anti-SERCA1 ATPase antibody [EPR7321]; Anti-SERCA1 ATPase antibody [EPR7321] at 1/10000 dilution + fetal muscle lysate at 10 ug.Predicted band size : 110 kDa.
Other-Anti-SERCA1 ATPase antibody [EPR7321](TA310206); Equilibrium disassociation constant (KD)..
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SERCA1 ATPase antibody [EPR7321]; Immunohistochemical analysis of paraffin-embedded human skeletal muscle tissue labelling SERCA1 ATPase using TA310206, at 1/100 dilution.