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Home Antibody All anti-ATG7 antibodies

Anti-ATG7 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306257 Rabbit Polyclonal APG7 Antibody 100ug $325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenAPG7 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human APG7.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 - 2 ug/ml, ICC: 10 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens autophagy related 7 (ATG7), transcript variant 2
Alternative NameAPG7-LIKE; APG7L; GSA7
Database LinkNP_001129503
Entrez Gene 10533 Human
Entrez Gene 74244 Mouse
FunctionAutophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2). This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1 (3). Another member of the autophagy family of proteins is APG7 which was identified in yeast as a ubiquitin-E1-like enzyme; this function is conserved in the mammalian homolog (4). In mammalian cells, APG7 is essential for autophagy conjugation systems, autophagosome formation, starvation-induced bulk degradation of proteins and organelles (5). It has been suggested that caspase-8 may alter APG7 levels and thus the APG7 program of autophagic cell death (6).
Related Pathway Regulation of autophagy

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of APG7 in Caco-2 cell lysate with APG7 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.
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Immunocytochemistry of APG7 in MCF7 cells with APG7 antibody at 10 ug/mL.
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