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Home Antibody All anti-ATG16L1 antibodies

Anti-ATG16L1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306514
  • Rabbit Polyclonal ATG16 Antibody
100ug 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenATG16 antibody was raised against a 18 amino acid peptide from near the center of human ATG16.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.25 - 0.5 ug/ml, ICC: 2 ug/ml, IF: 4 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens autophagy related 16-like 1 (S. cerevisiae) (ATG16L1), transcript variant 2
Alternative NameAPG16L; ATG16A; ATG16L; IBD10; WDR30
Database LinkNP_060444
Entrez Gene 55054 Human
Entrez Gene 77040 Mouse
Entrez Gene 363278 Rat
FunctionAutophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG16, another member of the autophagy protein family, forms a complex with the ATG5-ATG12 conjugate. This multimeric protein has been shown to be essential for autophagosome formation in both yeast and mammals and targets the ATG5-ATG12 complex to the autophagic isolation membrane during the formation of the autophagosome. Because mammalian ATG16 has seven WD-repeats in its C-terminal domain, it has been suggested that these may form a platform for further protein-protein interactions. Multiple isoforms of ATG16 are known to exist.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of ATG16 in HeLa cell lysate with ATG16 antibody at (A) 0.25 and (B) 0.5 ug/mL.
IF Image
Immunocytochemistry of ATG16 in HeLa cells with ATG16 antibody at 2 ug/mL.

 

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