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Home Antibody All anti-ATG12 antibodies

Anti-ATG12 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306512
  • Rabbit Polyclonal ATG12 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401486) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenATG12 antibody was raised against a 15 amino acid peptide from near the center of human ATG12.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens autophagy related 12 (ATG12), transcript variant 1
Alternative NameAPG12; APG12L; FBR93; HAPG12
Database LinkNP_004698
FunctionAutophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG12, another member of the autophagy protein family, forms a conjugate with ATG5; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist.
Related Pathway

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WB Image
Western blot analysis of ATG12 in mouse heart tissue lysate with ATG12 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
IHC Image
Immunohistochemistry of ATG12 in human brain tissue with ATG12 antibody at 2.5 ug/ml.

 

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