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Anti-ATF2 PHOSPHO Antibody
Also for ATF2 (NM_001880)
|Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser490/498 conjugated to KLH|
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000, IHC: 1:1000
|100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. |
|Homo sapiens activating transcription factor 2 (ATF2), transcript variant 1|
|CRE-BP1; CREB-2; CREB2; HB16; TREB7|
Entrez Gene 1386 Human
|This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined. [provided by RefSeq]. |
|Transcription FactorsDruggable Genome MAPK signaling pathway|
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Western blot of human melanoma cells incubated with varying doses of the radiomimetic drug NCS showing specific immuno-labeling of the ~74k ATF2 protein phosphorylated at Ser490 and Ser498.