Anti-ASGR2 Antibody, Clone 2A12

Also for ASGR2 (NM_001181)

OriGene Data

Immunogen	Full length human recombinant protein of human ASGR2 (NP_001172) produced in HEK293T cell.
Clone Name	Clone 2A12	Isotype	IgG2b
Species Reactivity	Human	Concentration	0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB 1:4000, IHC 1:150,
Buffer	PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification	Purified from mouse ascites fluids by affinity chromatography (Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens asialoglycoprotein receptor 2 (ASGR2), transcript variant 1
Alternative Name	ASGP-R2; ASGPR2; CLEC4H2; HBXBP; HL-2
Database Link	NP_001172
Function	This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
Related Pathway

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WB Image

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ASGR2 (RC213607, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ASGR2.

IHC Image

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-ASGR2 mouse monoclonal antibody. (TA505099)

IHC Image

Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-ASGR2 mouse monoclonal antibody. (TA505099)

IHC Image

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-ASGR2 mouse monoclonal antibody. (TA505099)

IHC Image

Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-ASGR2 mouse monoclonal antibody. (TA505099)

IHC Image

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-ASGR2 mouse monoclonal antibody. (TA505099)

IHC Image

Immunohistochemical staining of paraffin-embedded Human lymph node tissue using anti-ASGR2 mouse monoclonal antibody. (TA505099)

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OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Anti-ASGR2 TrueMAB Antibody Clone 2A12

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data