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Home Antibody All anti-ASAH1 antibodies

Anti-ASAH1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306621
  • Rabbit Polyclonal ASAH1 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC426805) , 20ug
100ug 325 In Stock
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WB(1)
IHC(1)
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Also for ASAH1 (NM_001127505)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenASAH1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of the human ASAH1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens N-acylsphingosine amidohydrolase (acid ceramidase) 1 (ASAH1), transcript variant 3
Alternative NameAC; ACDase; ASAH; PHP; PHP32; SMAPME
Database LinkNP_001120977
FunctionSphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH1 is an acid ceramidase and key regulator of ceramide metabolism. Mutations in this gene results in Farber Lipogranulomatosis, a fatal human genetic disorder that results in the painful swelling of the joints and tendons and pulminary insufficiency, while a complete knockout of its expression is lethal in mice. Recent studies have shown elevated levels of ASAH1 in Alzheimer’s disease (AD) patients correlating with a reduction in sphingomyelin and elevation of ceramide. Pretreatment of cultured neurons with recombinant AHAH1 prevented the cells from undergoing A-beta (Ab)-induced apoptosis. Multiple isoforms of this protein are known to exist.
Related Pathway

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WB Image
Western blot analysis of ASAH1 in mouse heart tissue lysate with ASAH1 antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of ASAH1 in human heart tissue with ASAH1 antibody at 2.5 ug/ml.

 

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