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Anti-ARRB1 PHOSPHO Antibody E109
Also for ARRB1 (NM_004041)
|synthetic phospho-peptide corresponding to residues surrounding Ser412 of human ß-Arrestin-1 was used as immunogen. The antibody only detects ß-Arrestin-1 phosphorylated on Serine 412.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, DB
||WB: 1:20,000; IHC: 1:500; ICC: 1:100-1:250; IP: 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Homo sapiens arrestin, beta 1 (ARRB1), transcript variant 1|
Entrez Gene 408 Human
Entrez Gene 109689 Mouse
Entrez Gene 25387 Rat
|Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. [provided by RefSeq]. |
|Druggable Genome MAPK signaling pathwayChemokine signaling pathwayEndocytosis|
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Western blot - beta Arrestin 1 (phospho S412) antibody [E109]; Anti-beta Arrestin 1 (phospho S412) antibody [E109] at 1/20000 dilution + 293T cell lysate.Predicted band size : 47 kDa.Observed band size : 50 kDa .
Immunohistochemistry (Paraffin-embedded sections) - beta Arrestin 1 (phospho S412) antibody [E109]; Ab32097, at a 1/500 dilution, staining beta Arrestin 1 in paraffin embedded human lymph node tissue by Immunohistochemistry.
Dot Blot - beta Arrestin 1 (phospho S412) antibody [E109]; Ab32097, at a dilution of 1/1000, staining beta Arrestin 1 by Dot Blot. .A nitrocellulose membrane was spotted with (1) phosphopeptide and (2) non phosphopeptide at 1 and 0.1ng and then blotted with TA303396.